Stanford AI Discovers Natural Molecule That Cuts Appetite by 50% in Animals

Stanford scientists, using artificial intelligence, identified a natural compound—BRP—that cuts food intake by up to half in laboratory animals. The molecule also accelerates fat loss while sparing muscle tissue. Unlike the current drug Ozempic, BRP does not trigger the digestive upset that often limits patient adherence. It works through a distinct neural circuit, offering a more targeted approach to appetite control. The discovery was made by training machine‑learning models on thousands of natural products, then testing the top candidates in mice. Early data show a 50% reduction in daily consumption and a measurable decrease in body fat after a short treatment period. The research team plans to advance the compound into preclinical safety studies next year, aiming to evaluate its pharmacokinetics and potential side‑effect profile before initiating human trials.