Pharmacists Warn Against Crushing Modified‑Release Tablets, Cite Overdose Risks

In a recent statement, pharmacists in Nigeria cautioned that crushing modified‑release tablets undermines their intended slow‑release design, potentially causing overdose, toxic side effects, and treatment failure. The warning follows growing concerns that patients who alter dosage forms may inadvertently expose themselves to higher drug concentrations and adverse reactions. Pharmacists emphasize that the integrity of the tablet’s coating and matrix is essential for maintaining a controlled release profile. By crushing the tablet, the drug is released all at once, negating the safety margin built into the formulation. The experts advise patients to follow prescribing instructions and to seek professional guidance before modifying any medication. Health professionals urge that any changes to dosage forms be discussed with a pharmacist or physician to avoid dangerous outcomes.