Long‑Term Melatonin Use May Double Heart Failure Risk in Chronic Insomnia Patients

Researchers analyzed data from a large cohort of adults with chronic insomnia who regularly took melatonin for several years. Over a five‑year follow‑up, those who used the supplement had a 90 percent higher incidence of heart failure compared with non‑users. The analysis was observational and cannot establish causation, but the association is statistically significant. The investigators caution that the findings do not prove melatonin causes heart disease, yet they highlight a potential safety concern for people who rely on the sleep aid for extended periods. The study calls for further research and suggests clinicians reassess long‑term melatonin prescriptions.