Targeting Immune Protein C3 May Replicate Calorie Restriction’s Anti‑Aging Effects

Researchers have identified the immune protein C3 as a key mediator of the anti‑aging benefits of moderate calorie restriction. In studies, lowering calorie intake reduced C3 levels, which in turn appeared to dampen chronic inflammation that accumulates with age. When scientists directly blocked C3 in mice, they observed a similar decline in age‑related inflammatory markers. These findings suggest that pharmacological inhibition of C3 could emulate the health‑span advantages of calorie restriction without the need for strict dieting. Further research will determine whether such treatments can safely extend healthy lifespan in humans.