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Restoring Brain Protein Menin Reverses Aging Markers in Mice

WHY IT MATTERS

By demonstrating that restoring Menin can reverse multiple aging phenotypes in mice, the study identifies a tangible molecular target that could lead to therapies for age‑related diseases in humans.

What happened

Scientists have shown that lowering levels of the brain protein Menin drive aging in mice. In experiments, mice with reduced Menin displayed increased inflammation, cognitive decline, bone loss, and skin thinning. When researchers reintroduced Menin, many of these age‑related changes reversed, restoring healthier tissue and function. The study also tested the amino acid D‑serine, which further improved cognitive performance in the animals. The findings suggest that Menin and D‑serine could become new targets for interventions aimed at slowing or reversing aging processes. Researchers plan to investigate the mechanisms behind Menin’s protective effects and evaluate whether similar strategies can be applied to human aging. The work opens a promising avenue for developing therapies that promote healthy longevity.

PRIMARY SOURCES

Scientists restore a brain protein and reverse signs of aging in mice

ScienceDaily · Discovery only; verify against the cited research or institution when available

Scientists restore a brain protein and reverse signs of aging in mice

ScienceDaily · Discovery only; verify against the cited research or institution before publication

CORRECTIONS & UPDATES

  1. Revision 1 · Initial ingestion · Sep 18, 2026, 11:15 AM
  2. Revision 2 · Source update detected · Sep 18, 2026, 11:15 AM
By THELAST.NEWS Editorial System · AI-assistedRevision 22 independent sources