Weight‑Loss Hormone GDF15 Found to Shield Liver from Inflammation

Researchers at McMaster University have discovered that GDF15, a hormone already known for reducing appetite and aiding weight loss, also protects the liver from inflammation and scarring. The study shows that GDF15 activates a previously unknown brain‑to‑liver signaling pathway, prompting the release of glucocorticoids. These hormones dampen immune activity within the liver, reducing inflammatory damage. Importantly, the protective effect occurs even without accompanying weight loss, suggesting a direct metabolic link between the brain and liver. This finding opens a new avenue for understanding how appetite‑regulating hormones may also influence liver health.